Personalized Cancer Care: Tailored Insights for Patients and Clinicians
At RGCC International, we provide advanced cancer diagnostics and liquid biopsy testing to support both patients and healthcare professionals, based on the principles of precision oncology.
Our cancer diagnostics support personalized treatment decisions, moving beyond a one-size-fits-all approach. By analyzing tumor-specific and genetic characteristics, the results provide insights that help clinicians design targeted, individualized treatment plans tailored to each patient’s unique disease profile.
RGCC International was founded in 2004 by genetics pioneer Dr. Ioannis Papasotiriou, with the goal of developing personalized treatment options for more effective cancer care. Today, that vision remains at the heart of everything we do.
Comprehensive Cancer Testing Solutions
Designed to deliver clinically relevant results throughout the entire cancer journey, RGCC diagnostics support early cancer detection, accurate monitoring, and informed treatment decisions through innovative, blood-based testing.
To achieve this, RGCC leverages precision medicine with advanced liquid biopsy tests to analyze circulating tumor cells (CTCs) and associated cancer markers in the bloodstream. This approach reveals the genetic composition of the cancer and enables individualized treatment approaches.
RGCC testing supports clinicians and patients at every stage of care.
RGCC Tests
Our range of cancer tests supports the principles of precision oncology by helping refine treatment strategies, improve therapeutic accuracy, and prioritize patient safety, ultimately supporting better patient outcomes.

Onco-D-Clare
Early detection can make all the difference. Onco-D-Clare can help identify cancer risk even before symptoms appear.
InVyomma Plus
focuses on gut microbiome profiling, including analysis of short-chain fatty acids, and their association with cancer.

Onconomics
provides highly detailed and accurate information about how effective specific anti-cancer drugs and targeted therapies are in treating…

Onconomics Plus
provides information about the effect of specific anti-cancer drugs, targeted therapies and natural treatments on the cancer…

Onconomics Extracts
is a unique and highly detailed test that provides information on how effective natural substances and plant…

Onconomics Extracts +
Onconomics Extracts+ provides highly detailed and accurate information about how effective specific natural substances and plant extracts are. Furthermore,…

Oncocount
detects the presence of CTCs and quantifies their concentration in the bloodstream. A higher number of CTCs might…

Oncotrace
establishes baseline values for CTC count, phenotype markers, and stemness markers in the bloodstream. These parameters provide a…

Oncotrail RGCC
is designed for specific cancers. It benchmarks the aggressiveness of the tumor and is used to track…

ArrayCGH RGCC
helps identify chromosomal abnormalities and genetic disorders.

ChemoSNiP
analyzes how each body reacts to a chemotherapy agent. It helps clinicians make superior decisions on which medication(s)…

CAMBISeq
is used to predict cancer treatment response. The test analyzes 500+ genes, which are used as biomarkers to…

Metastat
investigates the proteins that are related to the distant spread of cancer and the potential metastatic properties of…

Immune-Frame
provides insights into the current state of a patient’s immune system. It is used to guide treatment and…
Use our ‘smart filter’ to identify which test is best for your patients
Advancing Precision Oncology through Research & Innovation
RGCC’s research and development activities are dedicated to advancing precision oncology through innovative cancer diagnostics, liquid biopsy technologies, and personalized treatment approaches.
By combining molecular biology, genomics, cytogenetics, and advanced computational methods, our scientific team works to identify novel biomarkers, therapeutic targets, and diagnostic solutions that support more informed and individualized cancer care.
Through continuous innovation and rigorous scientific evaluation, RGCC remains committed to shaping the future of precision medicine and improving outcomes for cancer patients worldwide.
This commitment to scientific progress is also reflected in our growing portfolio of peer-reviewed publications and scientific articles, showcasing ongoing research, technological advancements, and discoveries in cancer diagnostics and personalized oncology.
Testimonials
V.S. (Prostate Cancer)
North America
Referred by a friend to an RGCC certified practitioner associated with prostate origin was detected at 1.8 cells/mL and currently has reduced to a lower risk level for future disease…
V.S. (Prostate Cancer)
North America
Referred by a friend to an RGCC certified practitioner associated with prostate origin was detected at 1.8 cells/mL and currently has reduced to a lower risk level for future disease activity at 1.4 cells/mL.
RGCC testing took the guesswork out of the equation and allowed a precisely targeted treatment. My practitioner has been very efficient and professional in creating the treatment plan and providing the necessary advice and tools to follow it. I recommend all cancer patients to schedule an interview to learn about their options regarding natural treatment of cancer.
S.B. (Endometrial Cancer)
North America
I had heavy periods which I thought caused an iron deficiency. My Primary Care ran blood tests and immediately sent me to the ER due to my hemoglobin at 4.3.…
S.B. (Endometrial Cancer)
North America
I had heavy periods which I thought caused an iron deficiency. My Primary Care ran blood tests and immediately sent me to the ER due to my hemoglobin at 4.3. After multiple trips to the ER for blood and ultrasounds my gynecologist finally ordered a D&C, and a tumor was found in my Uterus.
A total hysterectomy and six rounds of chemo-Carboplatin/Taxol (six weeks after my surgery). I moved forward with the total hysterectomy because they could not get my bleeding to stop. I went to the information sessions about Chemo and met with the medical oncologist but ultimately I declined Chemo.
As soon as I was diagnosed, my husband and I searched the internet for holistic and integrative doctors. I really wanted to find someone that did RGCC testing and my husband thought the Gerson protocols would work. I ran across Dr Donato and watched a few testimonials on YouTube, then decided to contact him. He quickly got back to me, and we did a short consult about a week after my surgery. It was important for me to meet him via video before committing to anything. I wanted whatever path I chose to be right for me.
Today I am three years cancer free, my CTC is low and still lowering. I have kept all my "checkups" with oncology and completed the CT's requested by oncology. But I have not done any chemo or radiation. My initial start was scary, I chose to go against the recommendation of my oncologist (chemo). I also had to adjust to taking a lot of supplements. Before my diagnosis I never liked taking pills so choosing my path was different. In the beginning I set alarms so I would not forget to take my supplements.
Dr Donato has changed life; I thank God every day for our paths crossing. I didn't want to get Chemo or radiation; Dr Donato was the answer I needed. The RGCC tests give you the knowledge you need so you are not blindly treating the cancer. It is important to have an expert develop the protocols and guide you along the way, Dr Donato is that expert. I fully believe in RGCC and Dr Donato. You cannot do this on your own! But you can do this with his help.
It is a lonely scary road to take a different path than what is "normal." But having someone like Dr Donato by your side makes the road easier to travel.
T. W. (Colon Cancer)
North America
I contracted colon cancer in 2018 and had a late-stage 3 tumor removed in 2019. I used your protocol of 9 enzymes and just passed 5 years cancer-free. My last…
T. W. (Colon Cancer)
North America
I contracted colon cancer in 2018 and had a late-stage 3 tumor removed in 2019. I used your protocol of 9 enzymes and just passed 5 years cancer-free. My last colonoscopy picked up a polyp, upon examination they found zero cancer cells in the polyp. Thank you very much for what you do. It saved my life.
P.W.
Europe
RGCC Laboratory has been a beacon of reliability and compassion in my cancer journey. Their cutting-edge tests not only provided me with a clear understanding of my diagnosis but also…
P.W.
Europe
RGCC Laboratory has been a beacon of reliability and compassion in my cancer journey. Their cutting-edge tests not only provided me with a clear understanding of my diagnosis but also guided my treatment decisions every step of the way. The peace of mind that comes from knowing I'm receiving the most advanced care possible is invaluable. I can't thank RGCC enough for their unwavering commitment to patients like me.
B.T. (Breast cancer)
North America
I have been involved with RGCC through my doctor for the last four years, due to early-stage breast cancer. Once a year I have done the Onconomics Plus, the Oncotrace…
B.T. (Breast cancer)
North America
I have been involved with RGCC through my doctor for the last four years, due to early-stage breast cancer. Once a year I have done the Onconomics Plus, the Oncotrace blood/lab work.
I have faithfully used the Onconomics Plus recommended supplements over the last four years. I can report that these modalities, together with lifestyle changes, have had a marked diminishing effect on my Circulating Tumor Cells (CTC), and keep them in a “low range”.
Additionally, follow-up mammograms and ultrasounds show the small areas of concern in my breast have not increased in size! I also had a small vaginal “cyst” that completely disappeared.
I sincerely believe that all of my RGCC-recommended treatments have been beneficial and have had a very healing and positive impact on my health over the last four years. I feel certain that through this early intervention, I have avoided much more serious breast cancer concerns in the future.
I also feel it’s very important to treat other viruses or ailments, as they wear the immune system down, impacting our body’s ability to function optimally & self-correct other potentially larger problems that may be brewing under the surface.
I truly feel that due to the insight of my doctor, who ordered the first RGCC lab work, I have been able to address the early-stage breast cancer concerns well in advance of the traditional medical community’s ability to detect any areas of concern.
Note: None of my previous annual mammograms revealed any areas of concern. On a gut feeling, I self-paid for a “Her Scan” ultrasound, which discovered the two small areas of concern in my right breast. After sharing this information with my doctor, he encouraged me to do the RGCC labs, revealing the Circulating Tumor Cells and gene mutations. I feel that without RGCC’s early diagnosis and intervention, I was headed toward serious health challenges, potentially resulting in a full-blown breast cancer diagnosis in my future.
I strongly encourage people to become involved with RGCC’s cutting-edge medical technologies and treatments. It helped me!
M. T. (Colon Cancer)
Southeast Asia
I felt lost after my colon cancer diagnosis. Traditional treatment options seemed harsh, and I craved a more holistic approach. Then I found RGCC. The blood test identified underlying issues…
M. T. (Colon Cancer)
Southeast Asia
I felt lost after my colon cancer diagnosis. Traditional treatment options seemed harsh, and I craved a more holistic approach. Then I found RGCC. The blood test identified underlying issues beyond the cancer itself. I feel more empowered to take control of my healing journey. RGCC gave me a second chance, and I’m determined to make the most of it.
C.N. (Pancreatic Cancer)
North America
My cancer was discovered during routine bloodwork. I was admitted on Friday, October 23rd, 2020. Before I was released the following Monday, my oncologist met with me to discuss my…
C.N. (Pancreatic Cancer)
North America
My cancer was discovered during routine bloodwork. I was admitted on Friday, October 23rd, 2020. Before I was released the following Monday, my oncologist met with me to discuss my options. I was told I have six months to live and with chemo I may have a year.
A friend recommended my RGCC certified practitioner because of his personal success with him. What seemed unmanageable is now manageable under his care. I've been under my practitioner's care for almost 5 years now. I have not had any chemo or radiation in over 18 months and I'm living a normal life. RGCC and my practitioner have tailored my treatment to my body and the results have been amazing. My traditional doctors are stunned by my results and refer to me as a unicorn.
L.O. (Breast Cancer)
North America
RGCC has been an integral part of my healing journey for the past 5 years. It has allowed me to receive specialized treatments for MY cancer. After being diagnosed with…
L.O. (Breast Cancer)
North America
RGCC has been an integral part of my healing journey for the past 5 years. It has allowed me to receive specialized treatments for MY cancer. After being diagnosed with Breast Cancer I felt like I was put on the conveyor belt of conventional therapies. Doctors were not looking at me as a person, just as the disease.
When I would ask about the Why behind things, I was generally told "because that's how we treat breast cancer." I never felt like they were treating me. I knew something was missing.
That's when I began to seek out other therapies. I found an amazing Integrative Doctor who led me to RGCC. As soon as I read the information about RGCC's specialized options for ME, I knew I had found my path.
Since starting RGCC I have never felt better.
My CTC was 5.6 (which is aggressive for breast cancer) and I am currently at 1.9 without chemo or radiation. I will continue until I reach 0. RGCC has helped save my life. I would highly recommend it to anyone considering alternative treatments.
I opt to get the Onconomics Plus yearly so I can see which supplements are working best against my cancer. I am always amazed at how much my cancer has adapted to the supplements from year to year. RGCC is specific for you and your cancer cells in real-time.
I now help others navigate their cancer diagnosis, so I see RGCC reports often, and I've never seen 2 be anywhere close to the same. What does that say for the Conventional medical model? We are unique individuals and so are our cancer cells.
Thank you to all the Scientists and Doctors who have given me a way to monitor my cancer cells in real time. You have indeed saved my life.

Dr. Clifford Fetters, MD
Health and Wellness of Carmel
RGCC helps guide my treatment decisions by testing circulating tumor cells to determine what therapies, whether chemotherapy, natural treatments, or supportive approaches, are most effective for each patient.

Dr. Clifford Fetters, MD
Health and Wellness of Carmel
RGCC helps guide my treatment decisions by testing circulating tumor cells to determine what therapies, whether chemotherapy, natural treatments, or supportive approaches, are most effective for each patient.

Dr. Tristin Wallace, ND
Inspiration Health & Wellness
RGCC's sensitive cell count test identified my patient's circulating malignant breast cancer cells.

Dr. Tristin Wallace, ND
Inspiration Health & Wellness
RGCC's sensitive cell count test identified my patient's circulating malignant breast cancer cells.

Dr. Christine Stueve, D.PSc., PhD, ND, DMBM
Founder NSIPM, Sano Consulting & Wellness Center, Lakeville, USA
I must express my gratitude and thankfulness for the incredible brilliance of the RGCC team. I had a large breast tumor in 2007 that was handled without chemo, radiation or…

Dr. Christine Stueve, D.PSc., PhD, ND, DMBM
Founder NSIPM, Sano Consulting & Wellness Center, Lakeville, USA
I must express my gratitude and thankfulness for the incredible brilliance of the RGCC team. I had a large breast tumor in 2007 that was handled without chemo, radiation or surgery. I did not know about RGCC until 2016 when the remaining CSCs and CTCs were discovered. As aggressive as these mutated cells have presented, I surely would have had recurrence in multiple areas of my system.
For my clients, I see a massive difference as I partner with RGCC assessments and walk them through resolving trauma and unresolved stress patterns.
I am forever grateful for Dr. Papasotiriou and the RGCC team!

Jesse Morse, M.D.
Osteopathic Center, Florida
If you or someone you love has CANCER, I urge you to look into RGCC testing. RGCC labs receive a sample of your blood, analyze it, break down its genetic…

Jesse Morse, M.D.
Osteopathic Center, Florida
If you or someone you love has CANCER, I urge you to look into RGCC testing. RGCC labs receive a sample of your blood, analyze it, break down its genetic sequence, and then give the following pieces of information:
- Circulating tumor cell count
- Specific gene markers/aggressiveness
- Which specific types of chemotherapy agents are effective against the cancer, which are ineffective, including percentages of effectiveness against your specific cancer
- Additionally, it will check over 100 non-traditional treatment options (including things like vitamin C, curcumin, mistletoe, etc.), to see if they are effective against your personal, specific cancer.
There are different tests to choose from, depending on the goal of the test. There is some coordination involved, but around 3 weeks following a simple blood draw, an extensive summary is provided to your oncologist/team of physicians. The company will actually spend plenty of time explaining and breaking down the test to the providers as well, so that you know exactly how to approach your personalized treatment going forward.
This is the future of cancer treatment. This is going to shake the industry in a good way. This is personalized cancer treatment at its finest. Gone are the days of guessing if a treatment plan is effective against a specific cancer. This test allows you to measure and calculate, not guess. For those wondering, they also have a screening test using the same techniques.
Global Presence, a Worldwide Network in Cancer Diagnostics
RGCC is a global organization dedicated to delivering advanced cancer diagnostics and exceptional service worldwide.
Through our international network of branch offices and trusted partners, we support patients and healthcare providers across all continents.
Headquartered in Switzerland, RGCC operates state-of-the-art laboratory facilities equipped with advanced technologies to ensure accurate and reliable results, wherever you are.

For healthcare practitioners
- Research and development
- Doctor's portal
- Not yet part of the RGCC network? Join our community of medical practitioners.

For patients
- Head to our patient site
- Contact us to be connected to a healthcare practitioner within our network
- Read testimonials from doctors and patients
Speak with your Doctor about RGCC Testing
RGCC cancer blood tests are designed to support personalized care and can be used alongside other diagnostic procedures. They are not intended to replace standard diagnostic methods or provide a definitive diagnosis on their own.
Our tests can offer valuable insights to help:
- Monitor cancer progression
- Identify genetic changes
- Support more tailored treatment decisions
Because every patient and cancer type is different, it’s important to speak with your oncologist and a specialist from our network about which test may be most appropriate for your individual condition.
Would you like to learn more about our testing methods? Explore our tests or contact us for more information.
Scientific Research & Innovation in Cancer Diagnostics
Explore the latest scientific advancements driving RGCC’s mission to transform cancer care through innovation in liquid biopsy and precision medicine.
Our dedicated research team continuously investigates the genetic, molecular, and immune profiles of cancer. As a result, we deepen our understanding of how the disease develops and how it responds to treatment.
Read our peer-reviewed publications and scientific abstracts to stay up to date with emerging insights in cancer diagnostics and personalized oncology.
News & Events
Learn more about our research, the latest publications and RGCC events.
Ambassador of Indonesia to Greece visits RGCC facilities in Florina
Florina, Greece
Indonesia’s Ambassador to Greece toured our Florina facilities. He was introduced to our innovative research activities and the high-quality…
RGCC Advocates for Equal Patient Access to Advanced Therapy Medicinal Products (ATMPs) Across the European Union
RGCC aims to promote transparency and collective action toward a fair and unified approach to healthcare access across the…
RGCC management meets with the Ambassador of Indonesia in Athens, Greece
Athens, Greece
RGCC International and Indonesia’s Ambassador explore partnerships to expand access to advanced healthcare, innovation, and regulatory cooperation.
As part of its CSR activities, RGCC Donates €15,000 to Support CAR-T Cell Therapy Research at Charité – Universitätsmedizin Berlin
RGCC International announces a €15,000 donation to Charité – Universitätsmedizin Berlin to support pioneering CAR-T cell therapy research for…
New Study Demonstrates Benefits of Circulating Tumor Cell Analysis in Ovarian Cancer Care
Powered by RGCC’s Onconomics test, circulating tumor cell (CTC) analysis is transforming ovarian cancer care — helping doctors personalize…
RGCC Supports “Kinder-Hilfe-Mobil” Initiative to Aid Children in Need in Halle (Saale), Germany
RGCC Central Europe has announced its support for CVJM Halle e. V., an organization dedicated to helping children living…