Colon Cancer Therapy: Established and New Treatment Options for Colorectal Cancer
The strategy for colon cancer therapy depends on various factors such as the location of the tumor, the stage of the disease and the patient's general status of health. Tumor histology and tumor biology also play an important role in determining which methods are used to treat colorectal cancer and how well the individual cancer will respond to therapy.
For years, clinicians have been achieving good outcomes for patients using established treatment methods such as surgery in combination with chemotherapy – especially if the colon cancer is detected early. In addition, modern medicine is constantly developing and testing new treatment methods for colorectal cancer that can target the cancer even more effectively. Below we present established procedures and new treatment methods such as personalized therapies for colorectal cancer.
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Table of Contents
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- Factors for Determining the Appropriate Therapy for Colon Cancer and Rectal Cancer
- Standard Methods in Colorectal Cancer Therapy: Surgery, Chemotherapy, Radiation Therapy
- Alternative Medicine and New Therapies: Targeted and Personalized Medicine
- Targeted Therapy for Colorectal Cancer
- Personalized Therapy
- Cancer Tests
- RGCC: Leading Experts in Cancer Genetics and Chemosensitivity Testing
Factors for Determining the Appropriate Therapy for Colon Cancer and Rectal Cancer
Colorectal cancer can occur in all areas of the bowel. Depending on the location of the tumor(s), it is referred to as colon carcinoma (cancer in the colon) or rectal carcinoma (cancer in the rectum). Doctors refer to them collectively as colorectal carcinoma or colorectal cancer. Sometimes it is also referred to as “bowel cancer” or “intestinal cancer”. In rare cases, this type of cancer can also occur in the appendix or small intestine.
Almost all bowel cancers start as a polyp, an abnormal tissue growth in the inner lining of the bowel or rectum. They usually appear in the form of small bumps in the intestinal mucosa. In most cases, a polyp is harmless and does not cause any symptoms. In fact, many people over the age of 50 have polyps in the colon or rectal area. However, in some cases, a polyp can become cancerous over the course of many years. Other causes and risk factors for the development of colon cancer include: too much red and processed meat and too little fiber and calcium in the diet, overweight or obesity, too little physical activity, smoking, alcohol, age, a family history of bowel cancer or other inherited gene changes, chronic bowel diseases like Ulcerative colitis or Crohn’s disease, bowel polyps (adenomas), type 2 diabetes, acromegaly, infections with Helicobacter pylori (H. pylori) or high energy (ionizing) radiation exposure.
The following factors, among others, are decisive in determining the appropriate treatment for colorectal cancer:
- Location of the tumor: Colorectal cancer usually affects the colon or rectum. The course of treatment depends on the affected area of the intestine and the exact location of the tumor.
- Stage of the disease: There are five different stages.
- Stage 0: The cancer is located exclusively in the uppermost layers of the intestinal mucosa.
- Stage I: The cancer is localized to the intestinal muscle layer.
- Stage II: The cancer has grown into surrounding tissue.
- Stage III: The cancer has invaded surrounding lymph nodes.
- Stage IV: The disease is advanced. The cancer has formed metastases (metastatic colorectal cancer) and has spread to other organs. The liver and lungs are frequently affected.
- Individual factors of the patient: These include age, physical condition and the presence of concomitant diseases. The patient's individual wishes and expectations can also be taken into account in colon/rectal cancer therapy, provided they do not negatively affect the success of the treatment.
- New disease or recurrence (relapse): Is the detected colon cancer a new disease, or has a previous cancer been diagnosed in this or another area? Is the tumor the primary tumor or is the primary tumor located in another organ?
The first three stages (stage 0, I and II) of the disease are considered early stages because the cancer has not yet metastasized. The earlier colorectal cancer is detected, the higher the chances of successful treatment and ideally even a complete cure. The location of the tumor primarily influences whether an artificial bowel outlet (stoma) is necessary following cancer therapy. However, this is only necessary in a few exceptional cases. If the intestinal cancer occurs in the rectum (rectal cancer) and is close to the anus, the sphincter muscle often has to be removed as part of the treatment. This requires a temporary or permanent artificial bowel outlet.
Standard Methods in Colorectal Cancer Therapy: Surgery, Chemotherapy, Radiation Therapy
In stage 0, it is often sufficient to remove the tumor during an endoscopic resection. As with a colonoscopy, a camera, as well as surgical instruments are inserted into the bowel via a tube. Then, only the affected area is surgically removed, the rest of the intestine remains intact.
In all other stages, patients usually have to undergo hemicolectomy surgery to remove as much of the colorectal cancer as possible. Surgery is the current standard procedure in colon cancer therapy and the most important therapeutic measure. During the operation, the part of the bowel affected by the cancer, the associated lymph channels and lymph nodes, as well as a sufficient amount of the surrounding healthy intestinal tissue are removed. Following surgery, the removed section of the bowel is examined in detail. The findings are then discussed by specialist physicians in order to determine the most effective treatment for the colon cancer.
As part of colon cancer therapy (colon carcinoma), chemotherapy following surgery can improve the success of treatment and secure it in the long term. This is particularly recommended for patients in stage III, when the cancer has already affected the surrounding lymph nodes. Patients in stage II can also benefit from chemotherapy.
As part of rectal cancer therapy, radiation chemotherapy or short-term radiotherapy is recommended before surgery. These are mainly used in stages II and III if the cancer is located in the middle or lower part of the rectum. These treatments are intended to shrink the tumor before surgery and reduce the risk of recurrence. Experts recommend radiation chemotherapy or, if necessary, chemotherapy after surgery (so-called “adjuvant therapy”) if the upper rectal area is affected, if the risk of recurrence is high or if this has not been carried out beforehand.
In most cases, chemotherapy, radiotherapy or a combination of these two methods are used in addition to surgery when treating colorectal cancer. As these therapy options are sometimes associated with severe side effects, new cancer treatment methods are constantly being researched, and their effectiveness is regularly tested in studies. The aim is to maximize the efficiency of colon and rectal cancer therapy while minimizing the side effects for patients.
Alternative Medicine and New Therapies: Targeted and Personalized Medicine
Targeted Therapy for Colorectal Cancer
There are new treatments for colorectal cancer that are designed to supplement and support standards therapies. One of these new methods is targeted therapy for colorectal cancer. This involves the use of newly developed active substances that are targeted against specific characteristics of the tumor. These characteristics may be specific proteins that are found in increased numbers on the surface of cancer cells or that are more important for the growth of cancer cells than in healthy tissue. Monoclonal antibodies developed in the laboratory are designed to inhibit tumor growth while largely sparing healthy cells. Research into molecular therapies for the treatment of colorectal cancer is constantly being expanded and intensified, with several ongoing clinical trials for the testing of new medication. The drugs for this new colon cancer therapy are used only when the corresponding markers have been detected in the tumor tissue by special cancer blood tests.
Personalized Therapy
An emerging branch of medicine is personalized cancer treatment. Here, too, cancer blood tests are of significant importance. Particularly in the area of colorectal cancer, numerous tumor markers and characteristics are well researched. With the help of specific blood tests, these can be identified. Subsequently, a personalized therapy – a treatment individually tailored to each patient – can be initiated. These new treatments for colorectal cancer aim to block the signalling pathways of the cancer cells to prevent their growth and cell division. At the same time, the body's own immune cells are stimulated.
Why is personalized therapy useful? It has been known for a long time that not all patients and tumors respond equally well to a particular form of treatment. This is not only due to the diverse characteristics of cancer cells. The genes, personal factors, the individual gastrointestinal microbiome and the location of the primary tumor can also lead to different causes underlying a disease and, for example, different ways in which the body processes medication. Thus, an alternative therapy response for colon cancer is needed to treat the highly individual forms of cancer effectively. Personalized therapy is designed to target colon or rectal cancer while sparing healthy cells as much as possible – unlike chemotherapy, which acts non-specifically against all rapidly growing cells in the body.
Personalized colorectal cancer treatment that precisely targets the patient's cancer aims to reduce the number of ineffective therapies.
Cancer Tests
New methods and reliable tests to enable personalized treatment. Speak to your healthcare provider to discuss which RGCC test can be used to diagnose colon cancer, detect specific biomarkers and personalize colon cancer treatment.
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Oncotrace
establishes baseline values for CTC count, phenotype markers, and stemness markers in the bloodstream. These parameters provide a…
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Oncocount
detects the presence of CTCs and quantifies their concentration in the bloodstream. A higher number of CTCs might…
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Oncotrail RGCC
is designed for specific cancers. It benchmarks the aggressiveness of the tumor and is used to track…
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Metastat
investigates the proteins that are related to the distant spread of cancer and the potential metastatic properties of…
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Onconomics
provides highly detailed and accurate information about how effective specific anti-cancer drugs and targeted therapies are in treating…
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Onconomics Plus
provides information about the effect of specific anti-cancer drugs, targeted therapies and natural treatments on the cancer…
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Onconomics Extracts
is a unique and highly detailed test that provides information on how effective natural substances and plant…
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Onconomics Extracts +
Onconomics Extracts+ provides highly detailed and accurate information about how effective specific natural substances and plant extracts are. Furthermore,…
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ChemoSNiP
analyzes how each body reacts to a chemotherapy agent. It helps clinicians make superior decisions on which medication(s)…
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Immune-Frame
provides insights into the current state of a patient’s immune system. It is used to guide treatment and…
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ArrayCGH RGCC
helps identify chromosomal abnormalities and genetic disorders.
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CAMBISeq
is used to predict cancer treatment response. The test analyzes 500+ genes, which are used as biomarkers to…
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Onco-D-Clare
Early detection can make all the difference. Onco-D-Clare can help identify cancer risk even before symptoms appear.
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InVyomma Plus
focuses on gut microbiome profiling, including analysis of short-chain fatty acids, and their association with cancer.
RGCC: Leading Experts in Cancer Genetics and Chemosensitivity Testing
The scientists at RGCC International are committed to addressing unmet medical needs and contributing to more targeted cancer treatment every day. Since 2004, we have been working with primary care and specialist physicians worldwide to provide the latest tests for cancer and chemosensitivity. As leading experts in cancer genetics and chemosensitivity testing, our goal is to detect possible signs of cancer early, monitor existing cancers, and develop a personalized profile of chemotherapy drugs and natural treatments that patients can benefit from.
Would you like to have an early cancer diagnosis, an analysis of the disease or therapy monitoring carried out using a blood test? Feel free to contact us! Our state-of-the-art tests and therapies are available exclusively to physicians in the RGCC network. In addition to colon cancer, our testing and therapy procedures can also be used to treat other types of cancer, such as prostate cancer, lung cancer, breast cancer and others. Do you have any further questions? Contact the highly specialized team at our help desk! We are happy to support you.













